Intravitreal Aflibercept Injection for Neovascular Age-related Macular Degeneration

Schmidt‐Erfurth, Ursula; Kaiser, Peter K.; Korobelnik, Jean‐François; Brown, David M.; Chong, Victor; Nguyen, Quan Dong; Ho, Allen C.; Ogura, Yuichiro; Simader, Christian; Jaffe, Glenn J.; Slakter, Jason S.; Yancopoulos, George D.; Stahl, Neil; Vitti, Robert; Berliner, Alyson J.; Soo, Yuhwen; Anderesi, Majid; Sowade, Olaf; Zeitz, Oliver; Norenberg, Christiane; Sandbrink, Rupert; Heier, Jeffrey S.

doi:10.1016/j.ophtha.2013.08.011

Ophthalmology

2014

DOI: 10.1016/j.ophtha.2013.08.011

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Intravitreal Aflibercept Injection for Neovascular Age-related Macular Degeneration

Ursula Schmidt‐Erfurth

¹

,

Peter K. Kaiser

²

,

Jean‐François Korobelnik

³

et al.

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Cited by 805 publications

(744 citation statements)

References 18 publications

Supporting

42

Mentioning

665

Contrasting

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31

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“…In this study, 1 case of nonserious intraocular inflammatory response was reported. This incidence of 0.03% is consistent with previous reports of IVT-AFL treatment 7 , 13 , 15 , 16 , 24 , 25 . Increased IOP after intravitreal anti-VEGF injection is a potential effect 26 .…”

Section: Discussionsupporting

confidence: 92%

“…Increased IOP after intravitreal anti-VEGF injection is a potential effect 26 . The incidence of OH and increased IOP in this cohort was 0.52% (Table 3 ) and is comparable to that reported previously 7 . Also, increased IOP was more likely develop during IVT-AFL treatment in eyes with comorbidities or medical history of glaucoma or OH 27 .…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Long-term surveillance provides real-world evidences of safety and effectiveness in intravitreal aflibercept treatment for age-related macular degeneration

Ozawa

¹

,

Ohgami

²

,

Sasaki

³

et al. 2023

Sci Rep

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…In this study, 1 case of nonserious intraocular inflammatory response was reported. This incidence of 0.03% is consistent with previous reports of IVT-AFL treatment 7 , 13 , 15 , 16 , 24 , 25 . Increased IOP after intravitreal anti-VEGF injection is a potential effect 26 .…”

Section: Discussionsupporting

confidence: 92%

“…Increased IOP after intravitreal anti-VEGF injection is a potential effect 26 . The incidence of OH and increased IOP in this cohort was 0.52% (Table 3 ) and is comparable to that reported previously 7 . Also, increased IOP was more likely develop during IVT-AFL treatment in eyes with comorbidities or medical history of glaucoma or OH 27 .…”

Section: Discussionsupporting

confidence: 91%

Long-term surveillance provides real-world evidences of safety and effectiveness in intravitreal aflibercept treatment for age-related macular degeneration

Ozawa

¹

,

Ohgami

²

,

Sasaki

³

et al. 2023

Sci Rep

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…These are lower percentages than seen in the View study (Schmidt‐Erfurth et al. ), where around 90% were stable after 2 years; however, the definition of maintaining VA was <15 letters loss, whereas it was defined as <5 letters loss in our study. Thus, even in the group that start with poor baseline VA, and where outcome VA is expected to be low, treatment is still worthwhile because they often gain many letters and stabilize at a higher level than before.…”

Section: Discussioncontrasting

confidence: 92%

Baseline visual acuity as a prognostic factor for visual outcomes in patients treated with aflibercept for wet age‐related macular degeneration: data from the INSIGHT study using the Swedish Macula Register

Lövestam‐Adrian

¹

,

Vassilev

²

,

Westborg

³

2018

Acta Ophthalmologica

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Central retinal thickness (CRT) evaluation was not corrected for OCT device type in the MATE‐EX study. Nevertheless, our data were in line with the VIEW, ALTAIR, ARIES, HAWK and HARRIER studies (Dugel et al, 2021; Mitchell et al, 2021; Ohji et al, 2020; Schmidt‐Erfurth et al, 2014), and other real‐world data (Eleftheriadou et al, 2018; Gayadine‐Harricham et al, 2020), showing that initial reductions in CRT occur following anti‐VEGF treatment and are sustained out to Months 24, 36 and 48. This supports the sustained effectiveness of a TEF posology.…”

Section: Discussionsupporting

confidence: 91%

Treatment of age‐related macular degeneration with aflibercept using a treat, extend and fixed protocol; A 4‐year study of treatment outcomes, durability, safety and quality of life (An extension to the MATE randomised controlled trial)

Airody

¹

,

Baseler

²

,

Seymour

³

et al. 2023

Acta Ophthalmologica

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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