Ophthalmology
 2014
DOI: 10.1016/j.ophtha.2013.08.012
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Intravitreal Aflibercept Injection for Macular Edema Resulting from Central Retinal Vein Occlusion

Jean‐François Korobelnik
1
,
Frank G. Holz
2
,
Johann Roider
3
et al.

Abstract: Treatment with intravitreal aflibercept provided significant functional and anatomic benefits after 52 weeks as compared with sham. The improvements achieved after 6 monthly doses at week 24 largely were maintained until week 52 with as-needed dosing. Intravitreal aflibercept generally was well tolerated.

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Cited by 276 publications

(338 citation statements)
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“…In our study, the mean number of injections for 12 months was 5.6, which was lower than the 9.8 in the CRUISE study, 3 and 11.8 in the GALILEO study. 4 Despite these results, there was a greater improvement in the VFQ-25 composite score in the present study than in other studies, suggesting that pro re nata (3 + PRN) is acceptable as a standard treatment for CRVO in terms of QOL.…”
Section: Discussioncontrasting
confidence: 96%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…In our study, the mean number of injections for 12 months was 5.6, which was lower than the 9.8 in the CRUISE study, 3 and 11.8 in the GALILEO study. 4 Despite these results, there was a greater improvement in the VFQ-25 composite score in the present study than in other studies, suggesting that pro re nata (3 + PRN) is acceptable as a standard treatment for CRVO in terms of QOL.…”
Section: Discussioncontrasting
confidence: 96%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Similar results have been reported in other trials. [22][23][24][25][26] In both the BRVO and CRVO groups, our BCVA results were in line with previously reported trial endpoints, but our patients required fewer intravitreal injections to achieve these outcomes. We speculate that this is due to the employment of fixed treatment plans and strict inclusion and exclusion criteria in clinical trials.…”
Section: Discussionsupporting
confidence: 90%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…“Conjunctival hemorrhage,” “eye pain,” and “vitreous floaters” were the most frequently reported ocular AEs in premarketing RCTs. w1–w25 These results were consistent to those reported in postmarketing studies. w26–w33 Similarly, both in pre- and postmarketing, “punctuated keratitis” was more reported with pegaptanib treatment w1–w4,w26 and “retinal hemorrhage” with intravitreal ranibizumab.…”
Section: Discussionsupporting
confidence: 90%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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