Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models

Liu, Xia; Taftaf, Rokana; Kawaguchi, Madoka; Chang, Ya-Fang; Chen, Wenjing; Entenberg, David; Zhang, Youbin; Gerratana, Lorenzo; Huang, Simo; Patel, Dhwani; Tsui, Elizabeth; Adorno-Cruz, Valery; Chirieleison, Steven M.; Cao, Yue; Harney, Allison S.; Patel, Shivani; Patsialou, Antonia; Shen, Yang; Avril, Stefanie; Gilmore, Hannah; Lathia, Justin D.; Abbott, Derek W.; Cristofanilli, Massimo; Condeelis, John S.; Liu, Huiping

doi:10.1158/2159-8290.cd-18-0065

Cancer Discovery

2019

DOI: 10.1158/2159-8290.cd-18-0065

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Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models

Xia Liu

¹

,

Rokana Taftaf

²

,

Madoka Kawaguchi

³

et al.

Abstract: Circulating tumor cells (CTCs) seed cancer metastases; however, the underlying cellular and molecular mechanisms remain unclear. CTC clusters were less frequently detected but more metastatic than single CTCs of triple negative breast cancer patients and representative patient-derived-xenograft (PDX) models. Using intravital multiphoton microscopic imaging, we found that clustered tumor cells in migration and circulation resulted from aggregation of individual tumor cells rather than collective migration and c… Show more

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Cited by 380 publications

(451 citation statements)

References 65 publications

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“…S1B; Supplementary Excel S1). Consistent with the literature ( 3, 25 ) and our previous findings ( 4, 15 ), the detection of CTC clusters at baseline is associated with an unfavorable OS ( n = 162, P = 0.0003; Supplementary Fig. S1D; Supplementary Table S1A).…”

Section: Resultssupporting

confidence: 91%

Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer

Dashzeveg

¹

,

Jia

²

,

Zhang

³

et al. 2023

Self Cite

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…S1B; Supplementary Excel S1). Consistent with the literature ( 3, 25 ) and our previous findings ( 4, 15 ), the detection of CTC clusters at baseline is associated with an unfavorable OS ( n = 162, P = 0.0003; Supplementary Fig. S1D; Supplementary Table S1A).…”

Section: Resultssupporting

confidence: 91%

Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer

Dashzeveg

¹

,

Jia

²

,

Zhang

³

et al. 2023

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…We found the potential binding site of FOXP3 in the promoter region of MTA1 and verified that FOXP3 can decrease the transcriptional activity of the MTA1 promoter and therefore inhibit MTA1 expression. Our results were also consistent with those of previous studies demonstrating that FOXP3 plays a regulatory role by directly binding to the promoters of downstream molecules, such as HER2, CD44 and VEGF ( 12 , 21 – 23 ). Based on the above suggestions, we assumed that the ability of FOXP3 to enter the nucleus as a transcription factor is a requirement for it to regulate downstream gene expression.…”

Section: Discussionsupporting

confidence: 93%

FOXP3 Inhibits the Metastasis of Breast Cancer by Downregulating the Expression of MTA1

Liu

¹

,

Han

²

,

Li

³

et al. 2021

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…This finding might suggest a role for additional HA receptors in maintaining cancer stem cell populations. Overall, our data support others [34], in which CD44 contributes to TNBC aggressiveness through adhesion and cytokine synthesis.…”

Section: Discussionsupporting

confidence: 92%

Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer

Witschen

¹

,

Chaffee

²

,

Brady

³

et al. 2020

Cancers

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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