Global long-term study on motor and non-motor symptoms and safety of levodopa-carbidopa intestinal gel in routine care of advanced Parkinson's disease patients; 12-month interim outcomes

²

,

³

et al. 2015

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The results confirm and strengthen the findings from earlier studies indicating an antidyskinetic effect of this treatment (12,15,(32)(33)(34)(35)(36). Our results are also in accord with previous studies concerning the effects on off-time and HRQoL in patients with PD.…”

Section: Discussionsupporting

confidence: 93%

Improvement of dyskinesias withl-dopa infusion in advanced Parkinson's disease

Timpka

¹

,

²

,

³

et al. 2015

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Patients treated with LCIG experienced a 57%, 87% and 75% reduction from BL in "Off" time at day 1, M18 and M24, respectively. This reduction in "Off" time was well above what is deemed clinically relevant [29] and was consistent with or even better than published open-label studies and randomised controlled trials on LCIG [8,[16][17][18][19][20][21][22][23][24][25][26] and higher compared to a 65% reduction in "Off" time at M24 demonstrated in the GLORIA registry [26]. In fact, in this sub-population analysis, we found a 77% reduction of the mean daily "Off" time compared to baseline.…”

Section: Discussionsupporting

confidence: 91%

Long-term effectiveness of levodopa-carbidopa intestinal gel on motor and non-motor symptoms in advanced Parkinson’s disease: results of the Italian GLORIA patient population

Antonini

¹

,

Marano²,

Gusmaroli

³

et al. 2020

Self Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…This study is the first overview of a cohort of Dutch PD patients treated with LCIG. The results of this study are similar to the findings of previous longterm studies reporting annual rates of withdrawal of 7-13% and an average overall duration of treatment of 7.6 years [10,13,14,16,[30][31][32]. In addition, all baseline characteristics of our cohort, the reported reasons for discontinuation, and the considerably high number of LCIG-related hospitalizations (i.e., serious adverse events) are comparable to the observations in other large patient groups [9,10,13,15,16,20,32].…”

Section: Discussionsupporting

confidence: 90%

Predictors of Time to Discontinuation of Levodopa-Carbidopa Intestinal Gel Infusion: A Retrospective Cohort Study

Moes

¹

,

Groenendal-Laurensse

²

,

Drent

³

et al. 2020

JPD

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.