Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil

Donald, Claire L.; Brennan, Benjamin; Cumberworth, Stephanie L.; Rezelj, Veronica V.; Clark, Jordan J.; Cordeiro, Marli Tenório; França, Rafael Freitas de Oliveira; Pena, Lindomar; Wilkie, Gavin S.; Filipe, Ana da Silva; Davis, Christopher; Hughes, Joseph; Varjak, Margus; Selinger, Martin; Zuvanov, Luíza; Owsianka, Ania M.; Patel, Arvind H.; McLauchlan, John; Lindenbach, Brett D.; Fall, Gamou; Sall, Amadou A.; Biek, Roman; Rehwinkel, Jan; Schnettler, Esther; Kohl, Alain

doi:10.1371/journal.pntd.0005048

PLoS Negl Trop Dis

2016

DOI: 10.1371/journal.pntd.0005048

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Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil

Claire L. Donald

¹

,

Benjamin Brennan

²

,

Stephanie L. Cumberworth

³

et al.

Abstract: BackgroundThe outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health concern. Little is currently known about the evolution and biology of ZIKV and the factors that contribute to the associated pathogenesis. Determining genomic sequences of clinical viral isolates and characterization of elements within these are an important prerequisite to advance our understanding of viral replicative processes a… Show more

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Cited by 241 publications

(220 citation statements)

References 64 publications

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213

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“…Through Sanger sequencing of the genome regions encompassing the M, E, NS1, NS3, NS4A, 2 K, and NS4B genes, it was confirmed that PE243 differs from SPH2015 due to the A2784G mutation, resulting in a missense substitution of amino acid R893G, as previously reported [ 14 ]. Additionally, an extra mutation (G6496A) was identified in the SPH2015 isolate, leading to a missense amino acid substitution (G2165E) in the NS4A protein (Additional file 1 ).…”

Section: Resultssupporting

confidence: 80%

Organotypic hippocampal culture model reveals differential responses to highly similar Zika virus isolates

Oliveira¹,

Cassiano

²

,

Pioline

³

et al. 2023

J Neuroinflammation

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Through Sanger sequencing of the genome regions encompassing the M, E, NS1, NS3, NS4A, 2 K, and NS4B genes, it was confirmed that PE243 differs from SPH2015 due to the A2784G mutation, resulting in a missense substitution of amino acid R893G, as previously reported [ 14 ]. Additionally, an extra mutation (G6496A) was identified in the SPH2015 isolate, leading to a missense amino acid substitution (G2165E) in the NS4A protein (Additional file 1 ).…”

Section: Resultssupporting

confidence: 80%

Organotypic hippocampal culture model reveals differential responses to highly similar Zika virus isolates

Oliveira¹,

Cassiano

²

,

Pioline

³

et al. 2023

J Neuroinflammation

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…Interestingly, we find that ZIKV infection generates not only RIG‐I agonists but also MDA5‐stimulatory RNAs. Dual activation of RIG‐I and MDA5 is consistent with the observation that IFN induction downstream of both RIG‐I and MDA5 is blocked by sfRNA, a subgenomic, non‐coding RNA expressed during ZIKV infection . Furthermore, infection with other members of the Flaviviridae family, such as hepatitis C virus, activates both RLRs .…”

Section: Discussionsupporting

confidence: 84%

Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling

Hertzog

¹

,

Dias

²

,

Rigby

³

et al. 2018

Self Cite

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…The difference in susceptibility to ZIKV infection between WT and Ifnar1 KO CNS cultures was marked, as anticipated from previous work [ 17 ]. The type I interferon receptor is composed of two polypeptide chains, IFNAR1 and IFNAR2, and binds all type I interferons; the archetypal antiviral cytokines.…”

Section: Discussionsupporting

confidence: 81%

Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected

Cumberworth

¹

,

Barrie

²

,

Cunningham

³

et al. 2017

acta neuropathol commun

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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