Alzheimer's & Dementia
 2012
DOI: 10.1016/j.jalz.2011.05.2416
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Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease

Michelle M. Mielke
1
,
Ozioma C. Okonkwo
2
,
Kenichi Oishi
3
et al.

Abstract: Background The fornix is the predominant outflow tract of the hippocampus, a brain region known to be affected early in the course of Alzheimer’s disease (AD). The aims of the present study were to: 1) examine the cross-sectional relationship between fornix DTI measurements (fractional anisotropy (FA), and mean (MD), axial (DA) and radial (DR) diffusivities), hippocampal volume, and memory performance, and 2) compare fornix DTI measures to hippocampal volumes as predictors of progression and transition from am… Show more

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Cited by 210 publications

(226 citation statements)
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“…This is in accordance with previous studies reporting significant associations between HRV and verbal memory recall [35]. The integrity of the fornix, which is the predominant outflow tract of the hippocampus, is predictive of memory performance and progression from MCI to AD [19]. This region is also implicated in autonomic control [6], suggesting that the fornix may form the anatomical location underlying the relationship between HRV and cognition.…”
Section: Resultssupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…This is in accordance with previous studies reporting significant associations between HRV and verbal memory recall [35]. The integrity of the fornix, which is the predominant outflow tract of the hippocampus, is predictive of memory performance and progression from MCI to AD [19]. This region is also implicated in autonomic control [6], suggesting that the fornix may form the anatomical location underlying the relationship between HRV and cognition.…”
Section: Resultssupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Abnormalities in all DTI metrics were observed in the fornices, corpus callosum, and posterior thalamic radiations, suggesting that these regions are particularly associated with AD pathology. Although previous studies have associated degeneration of the fornix specifically with DAT and episodic memory loss [24,25], our findings suggest that degeneration of this tract is not specific to DAT. It is possible that fornix involvement may reflect the fact that episodic memory loss, while severe in DAT, was also observed to a lesser degree in lvPPA and PCA, as others have reported [26,27].…”
Section: Discussioncontrasting
confidence: 96%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…The preservation of microstructure in left and right LV1 being associated with the younger individuals of our cohort is consistent with the ageing trajectories in other studies (Mielke et al, 2012; Pereira et al, 2014; Bussy et al, 2021). Similarly, left LV2 more likely to be associated with older adults in our study is also consistent with ageing trajectories in other studies (Gunbey et al, 2014; Carlesimo et al, 2010).…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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