Journal of Medical Virology
 2017
DOI: 10.1002/jmv.24910
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Evidence of increasing diversification of Zika virus strains isolated in the American continent

Fabián Aldunate
1
,
Fabiana Gámbaro
2
,
Álvaro Fajardo
3
et al.

Abstract: Zika virus (ZIKV) is a member of the family Flaviviridae. ZIKV emerged in Brazil in 2015, causing an unprecedented epidemic and since then the virus has rapidly spread throughout the Americas. These facts highlight the need of detailed phylogenetic studies to understand the emergence, spread, and evolution of ZIKV populations. For these reasons, a Bayesian coalescent Markov Chain Monte Carlo analysis of complete genome sequences of ZIKV strains recently isolated in the American continent was performed. The res… Show more

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Cited by 6 publications

(4 citation statements)
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“…The results shown in Table A1 were the outcome of 40 million steps of the MCMC, using the Tamura-Ney (TN93) + Γ model, a relaxed molecular clock, and the Bayesian Skyline model. The date of the most common ancestor to all ZIKV strains isolated in Latin America was estimated to be in early 2014 (95% HPD October 2013 to December 2014), in agreement with recent results [23,24,25]. A mean rate of evolution of 1.21 × 10 −3 substitutions per site per year (s/s/y) was found for the ZIKV sequences included in these studies (95% HPD 7.55 × 10 −4 to 1.66 × 10 −3 ).…”
Section: Resultssupporting
confidence: 88%
“…ZIKV genomes from strains isolated in the Latin American region and included in these studies fell into five different genetic lineages (Figure 1). This result highlighted an important degree of diversification in the ZIKV strains in this region, in agreement with previous studies done in America [23,25].…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…The results shown in Table A1 were the outcome of 40 million steps of the MCMC, using the Tamura-Ney (TN93) + Γ model, a relaxed molecular clock, and the Bayesian Skyline model. The date of the most common ancestor to all ZIKV strains isolated in Latin America was estimated to be in early 2014 (95% HPD October 2013 to December 2014), in agreement with recent results [23,24,25]. A mean rate of evolution of 1.21 × 10 −3 substitutions per site per year (s/s/y) was found for the ZIKV sequences included in these studies (95% HPD 7.55 × 10 −4 to 1.66 × 10 −3 ).…”
Section: Resultssupporting
confidence: 88%
“…ZIKV genomes from strains isolated in the Latin American region and included in these studies fell into five different genetic lineages (Figure 1). This result highlighted an important degree of diversification in the ZIKV strains in this region, in agreement with previous studies done in America [23,25].…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…the piece-wise nature of this method, which facilitates the identification of complex population changes. Coalescent theory has been a popular technique to infer population demographics underlying viral outbreaks [23][24][25][26][27][28][29][30][31][32]. By relating effective population size to the rate at which phylogenetic lineages converge backwards in time, the coalescent has become a powerful tool to infer demographic changes in the face of incomplete sampling.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…ZIKV has been responsible for several outbreaks including a recent and explosive epidemic in 2015-2016 where it swept through the Americas causing severe disease (Campos, Bandeira, & Sardi, 2015; Fauci & Morens, 2016; Lucchese & Kanduc, 2016). Importantly, although we still do not completely understand the molecular basis of ZIKV induced disease, viral genomic evolution has been implicated as a driving force for ZIKV disease and transmission in these recent epidemics (Aldunate, Gambaro, Fajardo, Sonora, & Cristina, 2017; Delatorre, Mir, & Bello, 2017; Y. Liu et al, 2017; Metsky et al, 2017; Shi et al, 2016; Yuan et al, 2017).…”
Section: Introductionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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