Diabetes Obesity Metabolism
 2016
DOI: 10.1111/dom.12670
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Efficacy and safety of sodium‐glucose co‐transporter‐2 inhibitors in type 2 diabetes mellitus: systematic review and network meta‐analysis

Francesco Zaccardi
1
,
David R. Webb
2
,
Zin Zin Htike
3
et al.

Abstract: Although they increase the risk of genital infection, SGLT2 inhibitors are effective in improving cardiometabolic markers in type 2 diabetes, with canagliflozin 300 mg performing better in this respect than other inhibitors. Further studies will clarify whether these differences are likely to translate into differing long-term outcomes.

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Cited by 481 publications

(482 citation statements)
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“…Furthermore, it is known that CEC tends to correlate with HDL-C levels [ 27 , 30 ]. However, contrary to ours and most other studies [ 31 ], serum HDL-C tended to decrease after dapagliflozin in that study [ 29 ]. Therefore, whether this difference in HDL-C responses after SGLT2i could have also contributed to the apparent discordant findings in CEC remains to be confirmed with further studies.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…Furthermore, it is known that CEC tends to correlate with HDL-C levels [ 27 , 30 ]. However, contrary to ours and most other studies [ 31 ], serum HDL-C tended to decrease after dapagliflozin in that study [ 29 ]. Therefore, whether this difference in HDL-C responses after SGLT2i could have also contributed to the apparent discordant findings in CEC remains to be confirmed with further studies.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Luseogliflozin and ipragliflozin were not associated with an increased risk of RTIs. Therefore, not all SGLT-2 inhibitors increased the risk of RTIs, which differed from a previous study ( 6 ). The participants in the luseogliflozin trial were all Japanese, and most of the participants included in the ipragliflozin trial were Japanese.…”
Section: Discussioncontrasting
confidence: 97%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…The incidence of genital infection was higher with dapagliflozin vs control in the present analysis, and this is consistent with other analyses of dapagliflozin, empagliflozin and canagliflozin . A meta‐analysis comparing all SGLT2 inhibitors with placebo observed a 4 to 6 times increased risk of genital infection with SGLT2 inhibitor use …”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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