Effectiveness of regional DTI measures in distinguishing Alzheimer's disease, MCI, and normal aging

Nir, Talia M.; Jahanshad, Neda; Villalón‐Reina, Julio E.; Toga, Arthur W.; Jack, Clifford R.; Weiner, Michael W.; Thompson, Paul M.

doi:10.1016/j.nicl.2013.07.006

NeuroImage: Clinical

2013

DOI: 10.1016/j.nicl.2013.07.006

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Effectiveness of regional DTI measures in distinguishing Alzheimer's disease, MCI, and normal aging

Talia M. Nir

¹

,

Neda Jahanshad

²

,

Julio E. Villalón‐Reina

³

et al.

Abstract: The Alzheimer's Disease Neuroimaging Initiative (ADNI) recently added diffusion tensor imaging (DTI), among several other new imaging modalities, in an effort to identify sensitive biomarkers of Alzheimer's disease (AD). While anatomical MRI is the main structural neuroimaging method used in most AD studies and clinical trials, DTI is sensitive to microscopic white matter (WM) changes not detectable with standard MRI, offering additional markers of neurodegeneration. Prior DTI studies of AD report lower fracti… Show more

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Cited by 357 publications

(393 citation statements)

References 126 publications

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“…Negative associations were observed between MD and both the COM-Mem and COM-EF composite scores, across all major white matter tracts at the 95% threshold for significance, with no significant positive associations observed. Taken together, these results replicate previous findings demonstrating that increased microstructural integrity is associated with better cognitive performance in both memory and executive functioning across all major white matter tracts (Crane et al, 2012; Gibbons et al, 2012; Nir et al, 2013).…”

Section: Resultssupporting

confidence: 90%

White Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older Adults

Halliday

¹

,

Gawryluk

²

,

García-Barrera

³

et al. 2019

Front. Hum. Neurosci.

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Negative associations were observed between MD and both the COM-Mem and COM-EF composite scores, across all major white matter tracts at the 95% threshold for significance, with no significant positive associations observed. Taken together, these results replicate previous findings demonstrating that increased microstructural integrity is associated with better cognitive performance in both memory and executive functioning across all major white matter tracts (Crane et al, 2012; Gibbons et al, 2012; Nir et al, 2013).…”

Section: Resultssupporting

confidence: 90%

White Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older Adults

Halliday

¹

,

Gawryluk

²

,

García-Barrera

³

et al. 2019

Front. Hum. Neurosci.

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…We also examined the correlations between 18 F-FDG-SUVR, DTI-FA, and DTI-MD from different brain regions and neuropsychological scores (MoCA and MMSE). In line with the previous literature [37–40], we showed that worse cognitive performance was strongly associated with decreased 18 F-FDG-SUVR and DTI-FA and increased DTI-MD.…”

Section: Discussionsupporting

confidence: 93%

Multimodal Classification of Alzheimer’s Disease and Amnestic Mild Cognitive Impairment: Integrated 18F-FDG PET and DTI Study

Li

¹

,

Zhao

²

,

Liu

³

et al. 2022

JAD

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…For all MAE metrics, these findings are consistent with our expectation that statistical deviation from the norm is greater in the MCI and dementia groups than in the CN group. Trends and directions of deviation for DTI metrics are also consistent with prior reports on regional DTI measures in AD 54,55 . Patterns of dementia and MCI effects were also mostly consistent across the two cohorts we examined, with stronger statistical significance in ADNI compared to NIMHANS.…”

Section: Resultssupporting

confidence: 87%

Microstructural Mapping of Neural Pathways in Alzheimer's Disease using Macrostructure-Informed Normative Tractometry

Feng

¹

,

Chandio

²

,

Villalón‐Reina

³

et al. 2024

Preprint

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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