Drug Addiction Endophenotypes: Impulsive Versus Sensation-Seeking Personality Traits

Ersche, Karen D.; Turton, Abigail J.; Pradhan, Shachi; Bullmore, Edward T.; Robbins, Trevor W.

doi:10.1016/j.biopsych.2010.06.015

Biological Psychiatry

2010

DOI: 10.1016/j.biopsych.2010.06.015

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Drug Addiction Endophenotypes: Impulsive Versus Sensation-Seeking Personality Traits

Karen D. Ersche

¹

,

Abigail J. Turton

²

,

Shachi Pradhan

³

et al.

Abstract: BackgroundGenetic factors have been implicated in the development of substance abuse disorders, but the role of pre-existing vulnerability in addiction is still poorly understood. Personality traits of impulsivity and sensation-seeking are highly prevalent in chronic drug users and have been linked with an increased risk for substance abuse. However, it has not been clear whether these personality traits are a cause or an effect of stimulant drug dependence.MethodWe compared self-reported levels of impulsivity… Show more

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Cited by 408 publications

(371 citation statements)

References 17 publications

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“…Dun & Rake's findings (2010), along with research findings, showed that student with high depression, academic achievement goals, and students with low depression choose functional goals. Also, in line with the findings of Ersche, Turton, Pradhan, Bullmore & Robbins (2010).in explaining the research hypothesis, learners who have received positive training mainly focus on improving their competencies and acquiring new knowledge, and to foment the failures The past is trying and doing homework that is hard and new, but people with high depression often choose more performance goals and prefer assignments that can be done without mistakes, so they are more likely to fail, and Most experience depression (Michinov, Brunot, Ohayel & Delaval ,2011).…”

Section: Resultssupporting

confidence: 91%

Effectiveness of Positive Thinking Skills Training on Depression in Female Students

Karimi¹,

Ahadi

²

,

Asadzadeh

³

2019

Iranian Journal of Educational Sociology

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Dun & Rake's findings (2010), along with research findings, showed that student with high depression, academic achievement goals, and students with low depression choose functional goals. Also, in line with the findings of Ersche, Turton, Pradhan, Bullmore & Robbins (2010).in explaining the research hypothesis, learners who have received positive training mainly focus on improving their competencies and acquiring new knowledge, and to foment the failures The past is trying and doing homework that is hard and new, but people with high depression often choose more performance goals and prefer assignments that can be done without mistakes, so they are more likely to fail, and Most experience depression (Michinov, Brunot, Ohayel & Delaval ,2011).…”

Section: Resultssupporting

confidence: 91%

Effectiveness of Positive Thinking Skills Training on Depression in Female Students

Karimi¹,

Ahadi

²

,

Asadzadeh

³

2019

Iranian Journal of Educational Sociology

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The cocaine users also reported more dysphoric mood compared with the healthy volunteers, which is not unusual for substance-dependent individuals ( Buckley et al , 2001 ). In keeping with previous research, the cocaine users reported increased trait-impulsivity and appetitive motivation (Moeller et al , 2004 ; 2005 ; Franken and Muris 2006 ; Ersche et al , 2010 ). However, these high levels of self-reported impulsivity were not reflected in their behavioural performance.…”

Section: Resultssupporting

confidence: 89%

Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence

Ersche

¹

,

Barnes

²

,

Jones

³

et al. 2011

Brain

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…The behavioral results reveal that the cognitive functions associated with accurate responses in the MID task are weakened among individuals high in either disinhibition or sensation-seeking levels. This finding is in line with previous observations that impulsivity dampens behavioral performance in cognitive tasks (Brown et al, 2012; Ersche et al, 2010; Kim & Lee, 2011). …”

Section: Discussionsupporting

confidence: 93%

Impulsive personality dimensions are associated with altered behavioral performance and neural responses in the monetary incentive delay task

Gu

¹

,

Jiang

²

,

Kiser

³

et al. 2017

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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