Disrupting Cholesterol-FOXO3-KRT14 axis suppresses metastasis of triple-negative breast cancer

Abstract: High metastatic propensity is a devastating challenge to effective therapy of solid tumors, including triple-negative breast cancer (TNBC). In this study, we performed a genome-scale screen and found that cholesterol homeostasis is essential for tumor progression in immunocompetent mice. In an orthotopic TNBC model, intracellular cholesterol promoted lung metastasis by sustaining the expression of keratin 14 (KRT14) and decreasing MHC II, which was indispensable for the cluster metastasis of TNBC. Mechanistic … Show more