Differential effects of the APOE genotype on brain function across the lifespan

Filippini, Nicola; Ebmeier, Klaus P.; MacIntosh, Bradley J.; Trachtenberg, Aaron; Frisoni, Giovanni B.; Wilcock, Gordon; Beckmann, Christian F.; Smith, Stephen M.; Matthews, Paul M.; Mackay, Clare E.

doi:10.1016/j.neuroimage.2010.08.009

NeuroImage

2011

DOI: 10.1016/j.neuroimage.2010.08.009

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Differential effects of the APOE genotype on brain function across the lifespan

Nicola Filippini

¹

,

Klaus P. Ebmeier

²

,

Bradley J. MacIntosh

³

et al.

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Cited by 193 publications

(191 citation statements)

References 83 publications

Supporting

25

Mentioning

164

Contrasting

2

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“…These results are discrepant with a previous study that did not observe interactive effects of APOE genotype and age on structural measures (Filippini, et al 2011). However, that study examined a smaller sample with two distinct age populations rather than a young to midlife adult sample with a continuous age range.…”

Section: Discussioncontrasting

confidence: 99%

APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults

Taylor

¹

,

Boyd

²

,

Turner

³

et al. 2016

Brain Imaging and Behavior

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…These results are discrepant with a previous study that did not observe interactive effects of APOE genotype and age on structural measures (Filippini, et al 2011). However, that study examined a smaller sample with two distinct age populations rather than a young to midlife adult sample with a continuous age range.…”

Section: Discussioncontrasting

confidence: 99%

APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults

Taylor

¹

,

Boyd

²

,

Turner

³

et al. 2016

Brain Imaging and Behavior

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…2b). Although earlier reports suggested that older adult 4 allele carriers have decreased fMRI BOLD activity in the hippocampus during memory tasks [42], our results demonstrate that this is only true in those who use the response strategy. Those who use a spatial strategy have significantly more fMRI BOLD activity in the hippocampus compared to those who use a response strategy.…”

Section: Resultscontrasting

confidence: 94%

Healthy versus Entorhinal Cortical Atrophy Identification in Asymptomatic APOE4 Carriers at Risk for Alzheimer’s Disease

Konishi

¹

,

Joober

²

,

Poirier

³

et al. 2018

Journal of Alzheimer’s Disease

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…We also found significant associations with APOE status in the CU and MCI individuals, in which larger brain-age deltas were associated with the presence of APOE -ε4 allele. This result is in line with previous literature that has shown that APOE -ε4 carriership may accelerate AD-related brain atrophy (Evans et al, 2014; Filippini et al, 2011), as accelerated brain aging has also been found in MCI and AD patients (Beheshti et al, 2018; Kaufmann et al, 2019). The association of brain-age delta with APOE -ε4 was also previously studied, for which significant associations were found in MCI individuals (J. H. Cole et al, 2018; Löwe et al, 2016).…”

Section: Discussionsupporting

confidence: 93%

Biological Brain Age Prediction Using Machine Learning on Structural Neuroimaging Data: Multi-Cohort Validation Against Biomarkers of Alzheimer’s Disease and Neurodegeneration stratified by sex

Cumplido‐Mayoral

¹

,

García‐Prat

²

,

Operto

³

et al. 2022

Preprint

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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