Nat Rev Drug Discov
 2012
DOI: 10.1038/nrd3681
|Get access via publisher |Summarize |Cite
|
Sign up to set email alerts

Diagnosing the decline in pharmaceutical R&D efficiency

Jack W. Scannell
1
,
Alex Blanckley2,
Helen Boldon3
et al.

Abstract: The past 60 years have seen huge advances in many of the scientific, technological and managerial factors that should tend to raise the efficiency of commercial drug research and development (RD). Yet the number of new drugs approved per billion US dollars spent on RD has halved roughly every 9 years since 1950, falling around 80-fold in inflation-adjusted terms. There have been many proposed solutions to the problem of declining RD efficiency. However, their apparent lack of impact so far and the contrast bet… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1,458
489
61
13

Citation Types

9
1,233
0
17

Year Published

2010
2010
2026
2026

Publication Types

Select...
1,440
255
143
121

Relationship

5
1,954

Authors

Journals

citations

Cited by 1,907 publications

(1,261 citation statements)
references

References 76 publications

9
1,233
0
17
Order By: Relevance
“…We found that relative to the semiconductor industry, firms in the pharmaceutical industry had lower R&D intensity, had lower patent intensity, and made fewer new product introductions during the time frame of our study. The trends we observed in the pharmaceutical industry are consistent with other recent findings on this industry (e.g., Scannell, Blanckley, Boldon, & Warrington, 2012). The lack of new product introductions in the pharmaceutical industry could be impacting the lack of support for Hypothesis 3.…”
Section: Limitations and Future Researchsupporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…We found that relative to the semiconductor industry, firms in the pharmaceutical industry had lower R&D intensity, had lower patent intensity, and made fewer new product introductions during the time frame of our study. The trends we observed in the pharmaceutical industry are consistent with other recent findings on this industry (e.g., Scannell, Blanckley, Boldon, & Warrington, 2012). The lack of new product introductions in the pharmaceutical industry could be impacting the lack of support for Hypothesis 3.…”
Section: Limitations and Future Researchsupporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…The decision-support integration of HAI at the stage of selecting development candidates to enter first-in-human studies could significantly increase the average clinical success rate of investigational new drugs from 7.9% 8 to 90.1% for nearly any disease 9, 10 . This result confirms that exponentially extracted knowledge alone may be sufficient to accurately predict clinical success, effecting a complete reversal of Eroom’s law 4 . The trained HAI is also the world’s first clinically validated model of human aging that could substantially speed up the discovery of preventive medicine for all age-related diseases 11 .…”
supporting
confidence: 76%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…A few explanations for our results can be introduced. As per cancer drugs, recent reports [11,14] show findings similar to ours and predict even greater sales and market share, due to the combination between high medical need and advances in the relevant science basis [6]. Advances in scientific knowledge bases sustaining R&D activities in oncology are worth mentioning here.…”
Section: Finding the Nichesupporting
confidence: 75%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
scite logo

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Status

Copyright © 2026 Scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.

Research Solutions Logo