Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

Wiviott, Stephen D.; Raz, Itamar; Bonaca, Marc P.; Mosenzon, Ofri; Kato, Eri; Cahn, Avivit; Silverman, Michael G.; Zelniker, Thomas A.; Kuder, Julia; Murphy, Sabina A.; Bhatt, Deepak L.; Leiter, Lawrence A.; McGuire, Darren K.; Wilding, John; Ruff, Christian T.; Gause‐Nilsson, Ingrid; Fredriksson, Martin; Johansson, Peter A.; Langkilde, Anna-Maria; Sabatine, Marc S.

doi:10.1056/nejmoa1812389

N Engl J Med

2019

DOI: 10.1056/nejmoa1812389

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Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

Stephen D. Wiviott

¹

,

Itamar Raz

²

,

Marc P. Bonaca

³

et al.

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Cited by 6,026 publications

(6,103 citation statements)

References 40 publications

Supporting

161

Mentioning

5,624

Contrasting

17

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291

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“…However, there is a limitation in the observations made in this open-label, single center study. In our study, there was no significant difference in CV related mortality between the two groups, which differs from other larger trials, such as EMPA-REG OUTCOME (Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients) and the DECLARE-TIMI 58 (Dapagliflozin Effect on Cardiovascular Events-Thrombolysis in Myocardial Infarction 58) [12,13]. The main reason is that only a few cases of CV events was observed, which may be attributed to the study design that was not focused on assessing CV outcomes.…”

Section: Discussioncontrasting

confidence: 99%

Long-term effectiveness and safety of quadruple combination therapy with empagliflozin versus dapagliflozin in patients with type 2 diabetes: 3-year prospective observational study

Ku

¹

,

Lee

²

,

Jeon

³

et al. 2021

Diabetes Research and Clinical Practice

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…However, there is a limitation in the observations made in this open-label, single center study. In our study, there was no significant difference in CV related mortality between the two groups, which differs from other larger trials, such as EMPA-REG OUTCOME (Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients) and the DECLARE-TIMI 58 (Dapagliflozin Effect on Cardiovascular Events-Thrombolysis in Myocardial Infarction 58) [12,13]. The main reason is that only a few cases of CV events was observed, which may be attributed to the study design that was not focused on assessing CV outcomes.…”

Section: Discussioncontrasting

confidence: 99%

Long-term effectiveness and safety of quadruple combination therapy with empagliflozin versus dapagliflozin in patients with type 2 diabetes: 3-year prospective observational study

Ku

¹

,

Lee

²

,

Jeon

³

et al. 2021

Diabetes Research and Clinical Practice

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Our analysis also showed that the magnitude of UACR reduction was similar in patients treated with and without RASi at baseline. This is in contrast to previous literature in which it has been proposed that SGLT-2 inhibition with concomitant RASi may synergistically boost the alternative RAS axis, leading to upregulation of angiotensin (1)(2)(3)(4)(5)(6)(7). 37 In our analysis, we did not find modulation by RASi or any indication of a possible synergistic effect, thus the effect of RASi is probably smaller.…”

Section: Discussioncontrasting

confidence: 99%

The effects of dapagliflozin on cardio‐renal risk factors in patients with type 2 diabetes with or without renin‐angiotensin system inhibitor treatment: a post hoc analysis

Scholtes

¹

,

Raalte

²

,

Correa‐Rotter

³

et al. 2019

Diabetes Obesity Metabolism

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…The EMPA-REG OUTCOME trial also showed that empagliflozin was superior to placebo, 6 diovascular Events-Thrombolysis in Myocardial Infarction 58) trial showed that dapagliflozin was noninferior to placebo for this composite outcome. 7 The reduction in hospitalization for heart failure seen in our trial is consistent with results of other trials of SGLT2 inhibitors. [5][6][7]18,19 The similar rates of amputation and fracture that we observed with canagliflozin and placebo are reassuring and consistent with trials of other SGLT2 inhibitors 6,7,20 but differ from the CANVAS Program findings.…”

Section: Discussionsupporting

confidence: 91%

“…7 The reduction in hospitalization for heart failure seen in our trial is consistent with results of other trials of SGLT2 inhibitors. [5][6][7]18,19 The similar rates of amputation and fracture that we observed with canagliflozin and placebo are reassuring and consistent with trials of other SGLT2 inhibitors 6,7,20 but differ from the CANVAS Program findings. 5 Whether the increased risk of lower limb amputation in the CANVAS Program was due to differing trial populations or protocols or to chance remains unclear.…”

Section: Discussionsupporting

confidence: 91%

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

Perkovic

¹

,

Jardine

²

,

Neal

³

et al. 2019

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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