Daclatasvir plus sofosbuvir, with or without ribavirin, achieved high sustained virological response rates in patients with HCV infection and advanced liver disease in a real-world cohort

Welzel, Tania M.; Petersen, Jörg; Herzer, Kerstin; Ferenci, Péter; Gschwantler, Michael; Wedemeyer, Heiner; Berg, Thomas; Spengler, Ulrich; Weiland, Ola; Valk, Marc van der; Rockstroh, Jürgen K.; Peck‐Radosavljevic, Markus; Zhao, Yue; Jiménez‐Expósito, María Jesús; Zeuzem, Stefan

doi:10.1136/gutjnl-2016-312444

Gut

2016

DOI: 10.1136/gutjnl-2016-312444

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Daclatasvir plus sofosbuvir, with or without ribavirin, achieved high sustained virological response rates in patients with HCV infection and advanced liver disease in a real-world cohort

Tania M. Welzel

¹

,

Jörg Petersen

²

,

Kerstin Herzer

³

et al.

Abstract: ObjectiveWe assessed the effectiveness and safety of daclatasvir (DCV) plus sofosbuvir (SOF), with or without ribavirin (RBV), in a large real-world cohort, including patients with advanced liver disease.DesignAdults with chronic HCV infection at high risk of decompensation or death within 12 months and with no available treatment options were treated in a European compassionate use programme. The recommended regimen was DCV 60 mg plus SOF 400 mg for 24 weeks; RBV addition or shorter duration was allowed at ph… Show more

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Cited by 199 publications

(169 citation statements)

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“…The highest SVR (96%) was witnessed with group D who took sofosbuvir plus daclatasvir; this was rather close to that achieved in a number of lab trials, for example, in phase IIA of LONESTAR open-label trial where the SVR was approximately 98%, 92%, and 89% for of genotype 1, 2, and 3, respectively (Cholongitas et al, 2014and Sulkowski et al in 2014). It was also in agreement with a study done by Welzel et al [20], where SVR12 was achieved by 91% of patients. In contrast to Fontaine et al in 2015, cirrhotic patients receiving SOF + DCV + RBF and sofosbuvir and simprevir achieved a 100% SVR thus was considered a good therapeutic option.…”

Section: Discussionsupporting

confidence: 93%

Dual versus triple therapy in treatment of hepatitis C virus (HCV)

Bishai

¹

,

Nabawy

²

,

El-Fiki

³

et al. 2022

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…The highest SVR (96%) was witnessed with group D who took sofosbuvir plus daclatasvir; this was rather close to that achieved in a number of lab trials, for example, in phase IIA of LONESTAR open-label trial where the SVR was approximately 98%, 92%, and 89% for of genotype 1, 2, and 3, respectively (Cholongitas et al, 2014and Sulkowski et al in 2014). It was also in agreement with a study done by Welzel et al [20], where SVR12 was achieved by 91% of patients. In contrast to Fontaine et al in 2015, cirrhotic patients receiving SOF + DCV + RBF and sofosbuvir and simprevir achieved a 100% SVR thus was considered a good therapeutic option.…”

Section: Discussionsupporting

confidence: 93%

Dual versus triple therapy in treatment of hepatitis C virus (HCV)

Bishai

¹

,

Nabawy

²

,

El-Fiki

³

et al. 2022

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Similarly, our results were in line with the research conducted by Welzel et al 12 Their study assessed the efficacy of daclatasvir and sofosbuvir across all genotypes. They found that HCV RNA was undetectable in 73% of cases at week 4 (Rapid Virological Response), while the End-of-Treatment Response (ETR) was 92%, and 99% of participants achieved SVR24.…”

Section: Discussionsupporting

confidence: 93%

Response of Daclatasvir and Sofosbuvir in Treatment-NaÃ¯ve, HCV Genotype 3, Non-Cirrhotic Pakistani Population: 1 Year Follow-Up Experience

Islam¹,

Aamir

²

,

Rana³

et al. 2023

Ann Pak Inst Med Sci

1

0

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Belperio et al 26 reported SVR12 rate in GT2 (94.5% without RBV and 88.1% with RBV) and GT3 (90.8% without RBV and 88.1% with RBV). In comparison to our response rate, similar findings are reported in other studies 22,27‐30 . These results supported that the chance of achieving a cure was higher with DCV + SOF then the DCV + SOF + RBV.…”

Section: Discussionsupporting

confidence: 93%

Direct‐acting antiviral agents in the treatment of chronic hepatitis C—Real‐life experience from clinical practices in Pakistan

Mushtaq

¹

,

Mansoor

²

,

Umar

³

et al. 2020

Journal of Medical Virology

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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