Daclatasvir plus sofosbuvir, with or without ribavirin, for hepatitis C virus genotype 3 in a French early access programme

Hézode, Christophe; Lebray, Pascal; Lédinghen, Victor de; Zoulim, Fabien; Martino, Vincent Di; Boyer, Nathalie; Larrey, Dominique; Botta‐Fridlund, Danielle; Silvain, Christine; Fontaine, Hélène; d’Altéroche, Louis; Leroy, Vincent; Bourlière, Marc; Hubert-Fouchard, I.; Guyader, Dominique; Rosa, Isabelle; Nguyen-Khac, Éric; Fedchuk, Larysa; Akremi, Raoudha; Bennai, Y.; Filipovics, Anne; Zhao, Yue; Bronowicki, Jean–Pierre

doi:10.1111/liv.13383

Liver International

2017

DOI: 10.1111/liv.13383

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Daclatasvir plus sofosbuvir, with or without ribavirin, for hepatitis C virus genotype 3 in a French early access programme

Christophe Hézode

¹

,

Pascal Lebray

²

,

Victor de Lédinghen

³

et al.

Abstract: Background & AimsOptimally effective treatment for hepatitis C virus genotype 3 (GT3) is urgently needed, particularly in advanced liver disease. Daclatasvir plus sofosbuvir was efficacious in phase 3 studies. Real‐world data for daclatasvir+sofosbuvir in advanced GT3 infection are presented from the French Temporary Authorisation for Use programme, which allowed patients in need without other treatment options access to daclatasvir ahead of its market authorization.MethodsPatients with F3/F4 fibrosis and/or e… Show more

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Cited by 78 publications

(80 citation statements)

References 16 publications

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“…Therefore, with the limitation of a selection bias determined by the decision to add RBV done on physician’s choices, rather than on randomization, our results suggest that in GT3 and compensated cirrhosis, on treatment with SOF/DCV, RBV and related side effects might be avoided, provided that a course of 24 weeks is adopted. Our results are in keeping with those reported by Hezode et al in GT3 patients with advanced liver disease from the French early access program [ 24 ] and with those by Cheung et al on mainly decompensated patients from the UK expanded access program [ 25 ].…”

Section: Discussionsupporting

confidence: 93%

Real life rates of sustained virological response (SVR) and predictors of relapse following DAA treatment in genotype 3 (GT3) patients with advanced fibrosis/cirrhosis

Mangia

¹

,

Losappio²,

Cenderello

³

et al. 2018

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…Therefore, with the limitation of a selection bias determined by the decision to add RBV done on physician’s choices, rather than on randomization, our results suggest that in GT3 and compensated cirrhosis, on treatment with SOF/DCV, RBV and related side effects might be avoided, provided that a course of 24 weeks is adopted. Our results are in keeping with those reported by Hezode et al in GT3 patients with advanced liver disease from the French early access program [ 24 ] and with those by Cheung et al on mainly decompensated patients from the UK expanded access program [ 25 ].…”

Section: Discussionsupporting

confidence: 93%

Real life rates of sustained virological response (SVR) and predictors of relapse following DAA treatment in genotype 3 (GT3) patients with advanced fibrosis/cirrhosis

Mangia

¹

,

Losappio²,

Cenderello

³

et al. 2018

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…Belperio et al 26 reported SVR12 rate in GT2 (94.5% without RBV and 88.1% with RBV) and GT3 (90.8% without RBV and 88.1% with RBV). In comparison to our response rate, similar findings are reported in other studies 22,27‐30 . These results supported that the chance of achieving a cure was higher with DCV + SOF then the DCV + SOF + RBV.…”

Section: Discussionsupporting

confidence: 93%

Direct‐acting antiviral agents in the treatment of chronic hepatitis C—Real‐life experience from clinical practices in Pakistan

Mushtaq

¹

,

Mansoor

²

,

Umar

³

et al. 2020

Journal of Medical Virology

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Among 4,907 patients, 1,431 patients were of GT3 with 96% (95% CI: 93–99%) prevalence of SVR12. In comparison to our response rate with SOF+DCV, similar outcomes are reported in other studies ( Nelson et al, 2015 ; Welzel et al, 2016 ; Goel et al, 2017 ; Hézode et al, 2017 ; del Rio-Valencia et al, 2018 ; Belperio et al, 2019 ). These findings supported that sustained virological responses are comparable between SOF+DCV and SOF/VEL.…”

Section: Discussionsupporting

confidence: 92%

Efficacy and Safety of Generic Sofosbuvir Plus Daclatasvir and Sofosbuvir/Velpatasvir in HCV Genotype 3-Infected Patients: Real-World Outcomes From Pakistan

Mushtaq

¹

,

Akhter

²

,

Khan

³

et al. 2020

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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