Front. Med.
 2022
DOI: 10.3389/fmed.2022.856891
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Corticosteroid Treatment Prevents Lipopolysaccharide-Induced Increase of ACE2 and Reduces Fibrin Degradation Products in Bronchoalveolar Lavage Fluid

Roman Reindl‐Schwaighofer
1
,
Farsad Eskandary
2
,
Johann Bartko
3
et al.

Abstract: The assessment of systemic corticosteroid effects on intrapulmonary disease biomarkers is challenging. This retrospective evaluation of a human endotoxemia model quantified ACE2 and fibrin degradation product (FDP) concentrations in bronchoalveolar lavage fluid (BALF) samples from a randomized, double-blind, placebo-controlled study (NCT01714427). Twenty-four healthy volunteers received either 2 × 40 mg intravenous dexamethasone or placebo. These doses were administered 12 h apart prior to bronchoscopy-guided … Show more

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Cited by 5 publications

(4 citation statements)
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“…The strong correlation between ACE2 and ALT-S provides evidence for unimpaired activity of the increased levels of soluble ACE2 (while it has been proposed that enzymatically inactive, truncated ACE2 variants are upregulated by in ammation) and for enzymatic cleavage of angiotensin II to angiotensin 1-7 primarily by ACE2 (and not by another unspeci ed peptidase) (26). We have recently shown that ACE2 increases in bronchoalveolar lavage uid following lipopolysaccharide instillation in a human endotoxemia model (27). To our best understanding, our data both add to our previous ndings (11) and align perfectly with an autopsy study from Belgium showing increased pulmonary ACE2 expression and decreased ACE expression in ARDS with or without COVID-19, when compared with unaffected controls (28).…”
Section: Ace-ssupporting
confidence: 87%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…The strong correlation between ACE2 and ALT-S provides evidence for unimpaired activity of the increased levels of soluble ACE2 (while it has been proposed that enzymatically inactive, truncated ACE2 variants are upregulated by in ammation) and for enzymatic cleavage of angiotensin II to angiotensin 1-7 primarily by ACE2 (and not by another unspeci ed peptidase) (26). We have recently shown that ACE2 increases in bronchoalveolar lavage uid following lipopolysaccharide instillation in a human endotoxemia model (27). To our best understanding, our data both add to our previous ndings (11) and align perfectly with an autopsy study from Belgium showing increased pulmonary ACE2 expression and decreased ACE expression in ARDS with or without COVID-19, when compared with unaffected controls (28).…”
Section: Ace-ssupporting
confidence: 87%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…The strong correlation between ACE2 and ALT-S provides evidence for unimpaired activity of the increased levels of soluble ACE2 (while it has been proposed that enzymatically inactive, truncated ACE2 variants are upregulated by inflammation) and for enzymatic cleavage of angiotensin II to angiotensin 1-7 primarily by ACE2 (and not by another unspecified peptidase) 28 . We have recently shown that ACE2 increases in bronchoalveolar lavage fluid following lipopolysaccharide instillation in a human endotoxemia model 29 . To our best understanding, our data both add to our previous findings 11 and align perfectly with an autopsy study from Belgium showing increased pulmonary ACE2 expression and decreased ACE expression in ARDS with or without COVID-19, when compared with unaffected controls 30 .…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Elevated AT1R expression enhances the biological effects of AngII, which exerts against NO overproduction, while decreased AT2R expression reduces vasodilatory factors and increases blood pressure, thereby improving the symptoms of septic shock. DXM was found to attenuate acute lung injury by inhibiting LPS-induced increase in ACE2 and reducing fibrin degradation products in bronchoalveolar lavage fluid [44].…”
Section: Plos Onementioning
confidence: 98%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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