Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate

Bonello, Laurent; Tantry, Udaya S.; Marcucci, Rossella; Blindt, Ruediger; Angiolillo, Dominick J.; Becker, Richard; Bhatt, Deepak L.; Cattaneo, Marco; Collet, Jean‐Philippe; Cuisset, Thomas; Gachet, Christian; Montalescot, Gilles; Jennings, Lisa K.; Dean, Larry S.; Sibbing, Dirk; Trenk, Dietmar; Werkum, Jochem W. van; Paganelli, Franck; Price, Matthew J.; Waksman, Ron; Gurbel, Paul A.

doi:10.1016/j.jacc.2010.04.047

Journal of the American College of Cardiology

2010

DOI: 10.1016/j.jacc.2010.04.047

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Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate

Laurent Bonello

¹

,

Udaya S. Tantry

²

,

Rossella Marcucci

³

et al.

Abstract: The addition of clopidogrel to aspirin treatment reduces ischemic events in a wide range of patients with cardiovascular disease. However, recurrent ischemic event occurrence during dual antiplatelet therapy, including stent thrombosis, remains a major concern. Platelet function measurements during clopidogrel treatment demonstrated a variable and overall modest level of P2Y(12) inhibition. High on-treatment platelet reactivity to adenosine diphosphate (ADP) was observed in selected patients. Multiple studies … Show more

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Cited by 1,114 publications

(944 citation statements)

References 101 publications

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876

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“…Our findings are not in agreement with the results of a recent metaanalysis [2], which reported a significantly higher risk of major adverse cardiovascular events in carriers of even one CYP2C19 LOF allele. The discrepancy could be attributed to the fact that the effect of one CYP2C19 LOF allele on the pharmacodynamic response of clopidogrel is less pronounced than two LOF alleles in Chinese patients.…”

Section: Discussioncontrasting

confidence: 99%

Effects of CYP2C19 variant alleles on postclopidogrel platelet reactivity and clinical outcomes in an actual clinical setting in China

Wu

¹

,

Qian

²

,

Xu

³

et al. 2012

Pharmacogenetics and Genomics

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Our findings are not in agreement with the results of a recent metaanalysis [2], which reported a significantly higher risk of major adverse cardiovascular events in carriers of even one CYP2C19 LOF allele. The discrepancy could be attributed to the fact that the effect of one CYP2C19 LOF allele on the pharmacodynamic response of clopidogrel is less pronounced than two LOF alleles in Chinese patients.…”

Section: Discussioncontrasting

confidence: 99%

Effects of CYP2C19 variant alleles on postclopidogrel platelet reactivity and clinical outcomes in an actual clinical setting in China

Wu

¹

,

Qian

²

,

Xu

³

et al. 2012

Pharmacogenetics and Genomics

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…We performed a subgroup analysis on different platelet function assays and found that LTA and MEA-guided IATs improved the combined endpoints of the CLR patients, whereas VASP- and VerifyNow-guided IAT did not. These results are consistent with reports that LTA and MEA are highly correlated to ischemic events[ 27 28 29 30 ] although Tang et al . [ 20 ] found that TEG-guided IAT also decreased the incidence of ischemic CV events compared to CAT.…”

Section: Discussionsupporting

confidence: 93%

Intensified Antiplatelet Treatment Reduces Major Cardiac Events in Patients with Clopidogrel Low Response

Xu

¹

,

Hu

²

,

Zhang

³

et al. 2016

Chinese Medical Journal

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…This is in accordance with previously published studies applying similar platelet function testing [12], [44]. We found that in clopidogrel responders, additional serotonin dose-dependently increased ADP-induced aggregation, i.e.…”

Section: Discussionsupporting

confidence: 93%

Serotonin Antagonism Improves Platelet Inhibition in Clopidogrel Low-Responders after Coronary Stent Placement: An In Vitro Pilot Study

Duerschmied

¹

,

Ahrens

²

,

Mauler

³

et al. 2012

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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