Cell
 2017
DOI: 10.1016/j.cell.2017.09.007
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Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

A. Gordon Robertson
1
,
Jaegil Kim
2
,
Guangwu Guo
3
et al.

Abstract: Summary We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the overall mutational load was associated with APOBEC-signature mutagenesis. Clustering by mutation signature identified a high-mutation subset with 75% 5-year survival. mRNA expression clustering refined prior clustering analyses and identified a poor-survival ‘neuronal’ subtype in which the majority of tumors lacked small cel… Show more

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Cited by 2,382 publications

(2,057 citation statements)
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“…To comprehensively characterize the extrachromosomal circular DNA landscape in UBC and gain insights into its role in genomic heterogeneity and instability, we performed whole-genome/exome sequencing (WGS/WES), Circle-Seq, single-molecule real-time (SMRT) long-read sequencing of circular DNA, and RNA sequencing (RNA-Seq) on 80 pairs of tumor and AT samples ( Figure 1 A and Table S2 ). Consistent with previous reports 4 , 5 , we observed a high tumor mutation load of UBC samples ( Figure S1 D ).…”
Section: Resultssupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…To comprehensively characterize the extrachromosomal circular DNA landscape in UBC and gain insights into its role in genomic heterogeneity and instability, we performed whole-genome/exome sequencing (WGS/WES), Circle-Seq, single-molecule real-time (SMRT) long-read sequencing of circular DNA, and RNA sequencing (RNA-Seq) on 80 pairs of tumor and AT samples ( Figure 1 A and Table S2 ). Consistent with previous reports 4 , 5 , we observed a high tumor mutation load of UBC samples ( Figure S1 D ).…”
Section: Resultssupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…PLEKHS1 promoter and FGRG3 missense mutations were the next most frequently observed variants, at 38.3% and 36.2%, respectively, followed by TP53 mutations at 31.9%. Consistent with previous reports [ 48 ], FGFR3 and TP53 mutations are the most powerful indicators of cancer grade, with FGFR3 mutations enriched in LG and TP53 mutations enriched in HG tumors ( Figure 2 A,C). Genes responsible for encoding critical effectors and regulators of chromatin remodeling were also frequently mutated and enriched for deletion events.…”
Section: Resultssupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…4A). This frequency is consistent with previously reported in other MIBC cohorts 12,26,27 , highlighting their role as BC drivers.…”
Section: Resultssupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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