Sci Rep
 2016
DOI: 10.1038/srep38907
|Get access via publisher |Summarize |Cite
|
Sign up to set email alerts

CircRNA accumulation in the aging mouse brain

Hannah N. Gruner
1
,
Mariela Cortés-López
2
,
Daphne Cooper
3
et al.

Abstract: Circular RNAs (circRNAs) are a newly appreciated class of RNAs expressed across diverse phyla. These enigmatic transcripts are most commonly generated by back-splicing events from exons of protein-coding genes. This results in highly stable RNAs due to the lack of free 5′ and 3′ ends. CircRNAs are enriched in neural tissues, suggesting that they might have neural functions. Here, we sought to determine whether circRNA accumulation occurs during aging in mice. Total RNA-seq profiling of young (1 month old) and … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
366
94
59
20

Citation Types

29
304
4
0

Year Published

2017
2017
2026
2026

Publication Types

Select...
289
145
40
18

Relationship

9
483

Authors

Journals

citations

Cited by 458 publications

(337 citation statements)
references

References 52 publications

29
304
4
0
Order By: Relevance
“…Here, by generating and analyzing deep RNA sequencing data of 164 blood samples collected from the long-lived families, we conducted a genome-wide investigation of circRNA expression patterns in a long-lived Chinese cohort for the first time. Different from the previous observations that circRNAs appear to accumulate with age in the neural tissues of mice [41], Drosophila [42] and Caenorhabditis elegans [43], we found that the overall circRNA expression in the LLIs was significantly lower than that in the younger controls (viz., F1SPs). As circRNAs are expressed in a tissue-specific manner [14] and not easily degraded by nucleases owing to the special loop structure [44], our result indicated that there may be some potential circRNA degradation or generation mechanism in peripheral blood of the longevous individuals.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Here, by generating and analyzing deep RNA sequencing data of 164 blood samples collected from the long-lived families, we conducted a genome-wide investigation of circRNA expression patterns in a long-lived Chinese cohort for the first time. Different from the previous observations that circRNAs appear to accumulate with age in the neural tissues of mice [41], Drosophila [42] and Caenorhabditis elegans [43], we found that the overall circRNA expression in the LLIs was significantly lower than that in the younger controls (viz., F1SPs). As circRNAs are expressed in a tissue-specific manner [14] and not easily degraded by nucleases owing to the special loop structure [44], our result indicated that there may be some potential circRNA degradation or generation mechanism in peripheral blood of the longevous individuals.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…TUNEL staining showed that the percentage of dead cells was significantly increased. Previous studies have reported increased circRNA expression in the brain during aging ( Gruner et al, 2016 ; Xu et al, 2018 ); however, this trend was not observed in our study in the rat SAT. Our results are consistent with previous studies on the heart and muscle tissues ( Kotb Abdelmohsen et al, 2015 ; Gruner et al, 2016 ).…”
Section: Discussioncontrasting
confidence: 99%
“…Previous studies have reported increased circRNA expression in the brain during aging ( Gruner et al, 2016 ; Xu et al, 2018 ); however, this trend was not observed in our study in the rat SAT. Our results are consistent with previous studies on the heart and muscle tissues ( Kotb Abdelmohsen et al, 2015 ; Gruner et al, 2016 ). The reasons why the expression of circRNAs in adipose tissue does not increase significantly with age are unclear and further studies are required in elucidating them.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…An identical pattern was seen in the frontal lobe AD samples, and correlation between AD and control was moderate (R 2 = 0.3928) ( S12A and S12B Fig and S22 Table ). This is consistent with observations from previous studies in rodents demonstrating that circRNAs are enriched at synapses [ 39 , 46 , 53 , 54 ]. Next, we compared circRNA expression differences between AD and control in the frontal lobe homogenate samples ( Fig 5D and S23 Table ).…”
Section: Resultssupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
scite logo

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Status

Copyright © 2026 Scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.

Research Solutions Logo