Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol

Casson, Cierra N.; Copenhaver, Alan M.; Zwack, Erin E.; Nguyen, Hieu; Strowig, Till; Javdan, Bahar; Bradley, William P.; Fung, Thomas C.; Flavell, Richard A.; Brodsky, Igor E.; Shin, Sunny

doi:10.1371/journal.ppat.1003400

PLoS Pathog

2013

DOI: 10.1371/journal.ppat.1003400

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Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol

Cierra N. Casson

¹

,

Alan M. Copenhaver

²

,

Erin E. Zwack

³

et al.

Abstract: Inflammasome activation is important for antimicrobial defense because it induces cell death and regulates the secretion of IL-1 family cytokines, which play a critical role in inflammatory responses. The inflammasome activates caspase-1 to process and secrete IL-1β. However, the mechanisms governing IL-1α release are less clear. Recently, a non-canonical inflammasome was described that activates caspase-11 and mediates pyroptosis and release of IL-1α and IL-1β. Caspase-11 activation in response to Gram-negati… Show more

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Cited by 172 publications

(231 citation statements)

References 88 publications

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209

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“…Caspase-11 has been shown to play a significant role during Klebsiella pneumoniae infection by recruiting neutrophils and controlling bacterial burdens (32), largely through the cleavage and release of IL-1␣. A similar association of caspase-11 and IL-1␣ and their role in neutrophil recruitment were observed in Legionella pneumophila and Yersinia pseudotuberculosis infections (33). While we observed differences in oviduct neutrophil levels, we did not detect any differences in IL-1␣ levels in cervical secretions (see Fig.…”

Section: Discussionsupporting

confidence: 86%

Caspase-11 Contributes to Oviduct Pathology during Genital Chlamydia Infection in Mice

Allen

¹

,

Gyorke

²

,

Tripathy

³

et al. 2019

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…Caspase-11 has been shown to play a significant role during Klebsiella pneumoniae infection by recruiting neutrophils and controlling bacterial burdens (32), largely through the cleavage and release of IL-1␣. A similar association of caspase-11 and IL-1␣ and their role in neutrophil recruitment were observed in Legionella pneumophila and Yersinia pseudotuberculosis infections (33). While we observed differences in oviduct neutrophil levels, we did not detect any differences in IL-1␣ levels in cervical secretions (see Fig.…”

Section: Discussionsupporting

confidence: 86%

Caspase-11 Contributes to Oviduct Pathology during Genital Chlamydia Infection in Mice

Allen

¹

,

Gyorke

²

,

Tripathy

³

et al. 2019

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…4C, 6D, and 7B); this result is supported by previous observations that NLRP3 and ASC are dispensable for the restriction of L. pneumophila replication in vivo (18,19,35). Notably, caspase-11 facilitated the recruitment of neutrophils to the sites of infection via the induction of IL-1a (40). This feature should favor a role for caspase-11 in the restriction of L. pneumophila replication in vivo.…”

Section: Discussionsupporting

confidence: 82%

Caspase-1 but Not Caspase-11 Is Required for NLRC4-Mediated Pyroptosis and Restriction of Infection by Flagellated Legionella Species in Mouse Macrophages and In Vivo

Cerqueira

¹

,

Pereira

²

,

Silva

³

et al. 2015

The Journal of Immunology

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…S5A and B in the supplemental material), consistent with previous studies indicating that neutrophil recruitment is T4SS dependent (20,28,30,60 identified alveolar macrophages as being positive for T4SS-mediated injection, but we also could identify injected cells that expressed high levels of Ly6G and were negative for MHC-II (Fig. 3B).…”

Section: A Reporter System Tracks Translocation Of Type IV Secretion supporting

confidence: 90%

Alveolar Macrophages and Neutrophils Are the Primary Reservoirs for Legionella pneumophila and Mediate Cytosolic Surveillance of Type IV Secretion

Copenhaver

¹

,

Casson

²

,

Nguyen

³

et al. 2014

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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