American Journal of Ophthalmology
 2011
DOI: 10.1016/j.ajo.2010.08.015
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ARMS2/HTRA1 Locus Can Confer Differential Susceptibility to the Advanced Subtypes of Age-Related Macular Degeneration

Lucia Sobrin
1
,
Robyn Reynolds
2
,
Yi Yu
3
et al.

Abstract: Purpose To determine if genetic variants that have been associated with age-related macular degeneration (AMD) have a differential effect on the risk of choroidal neovascularization (CNV) and geographic atrophy. Design Genetic association study. Methods Setting Multicenter study. Study Population Seven hundred forty-nine participants with geographic atrophy and 3209 participants with CNV were derived from 4 AMD studies with similar procedures from Tufts Medical Center, the Age-Related Eye Disease Study,… Show more

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Cited by 77 publications

(60 citation statements)
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“…Association signals at CFH , C2 , CFB , C3 , CFI and ARMS2/HTRA1 were also significant for both GA and NV compared with controls. ARMS2/HTRA1 was more strongly related to NV compared with GA as previously reported ( 23 ).…”
Section: Resultssupporting
confidence: 86%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Association signals at CFH , C2 , CFB , C3 , CFI and ARMS2/HTRA1 were also significant for both GA and NV compared with controls. ARMS2/HTRA1 was more strongly related to NV compared with GA as previously reported ( 23 ).…”
Section: Resultssupporting
confidence: 86%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…In contrast, this large GWAS meta-analysis did have sufficient power to firmly document our previous finding from a candidate gene case-control association study. In that prior study the locus had a moderate effect size with an OR of 1.37 which was quite consistent with the OR of 1.38 observed in this study, 23 suggesting about a 38% higher risk of developing CNV vs. GA with each T allele a participant harbors.…”
Section: Discussionsupporting
confidence: 87%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…These sub-analyses of the full GWAS dataset did not uncover additional loci reaching p<5×10 −8 ; furthermore heterogeneity near CFH and ARMS2 remained significant in all sub-analyses (I 2 >65%, p <.001). Consistent with previous reports 17,29,30 , separate analysis of NV and GA cases showed ARMS2 risk alleles preferentially associated with risk of NV (OR NV =2.97, OR GA =2.50, p difference =.0008) whereas CFH risk alleles preferentially associated with risk of GA (OR NV =2.34, OR GA =2.80, p difference =.0006). We also observed large differences in effect sizes when stratifying by ethnicity, with variants near CFH exhibiting stronger evidence for association among Europeans (p=.0000001) and those near TNFRSF10A among East Asians (p=.002).…”
supporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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