The FASEB Journal
 2001
DOI: 10.1096/fj.01-0457fje
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Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation

Florence Massiéra
1
,
May Bloch-Faure
2
,
Debbie L. Ceiler
3
et al.

Abstract: White adipose tissue and liver are important angiotensinogen (AGT) production sites. Until now, plasma AGT was considered to be a reflection of hepatic production. Because plasma AGT concentration has been reported to correlate with blood pressure, and to be associated with body mass index, we investigated whether adipose AGT is released locally and into the blood stream. For this purpose, we have generated transgenic mice either in which adipose AGT is overexpressed or in which AGT expression is restricted to… Show more

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Cited by 475 publications

(435 citation statements)
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“…In this study, in obese and mostly normotensive patients, we found no relationship between blood pressure and adipose AGT secretion. These data do not support the possible role of locally produced adipocyte‐derived AGT in blood pressure, in contrast to previous reports in animals, especially in transgenic mice (14). In humans, the question of whether the RAS in adipose tissue could provide a link between obesity and hypertension remains unclear (25).…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…In this study, in obese and mostly normotensive patients, we found no relationship between blood pressure and adipose AGT secretion. These data do not support the possible role of locally produced adipocyte‐derived AGT in blood pressure, in contrast to previous reports in animals, especially in transgenic mice (14). In humans, the question of whether the RAS in adipose tissue could provide a link between obesity and hypertension remains unclear (25).…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Consistent with previous results [6, 15, 16], total body weight and epididymal fat pad mass of Agt -KO mice were significantly lower than those of WT controls. Re-expressing Agt solely in adipose tissue through the use of an adipocyte-specific promoter increased both body and fat pad weights relative to those of Agt-KO mice (8.5% and 20%, resp), but neither change was statistically significant.…”
Section: Resultssupporting
confidence: 92%
“…Elevating adipose Agt expression in WT mice is associated with reduced AGTR2 but normal AGTR1 levels, indicating a potential feedback mechanism to control AGTR2 receptor expression in accordance with local Ang II production. Consistent with data in Figure 1, we previously reported that overexpressing Agt in adipose tissue increased AGT content by ∼ 50% over WT [6]. …”
Section: Resultssupporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…As expected, the aP2‐Agt Tg mice had higher adipose Agt levels (5.2 ± 3.9, 16.9 ± 8.6, 15.9 ± 7.7, and 20.4 ± 10.8 µg/g protein in female wild‐type (Wt), female Tg, male Wt, and male Tg respectively; P < 0.05 for genotype effect) at the age of 24‐weeks. It is worth noting that similar results have been reported previously for Agt secretion from adipose explants (18) and adipocytes isolated from these mice (24). The transgenics also had ∼20% higher plasma Agt levels () than the Wt mice, also in agreement with previous reports (18).…”
Section: Resultssupporting
confidence: 89%
“…It is worth noting that similar results have been reported previously for Agt secretion from adipose explants (18) and adipocytes isolated from these mice (24). The transgenics also had ∼20% higher plasma Agt levels () than the Wt mice, also in agreement with previous reports (18). Because female aP2‐Agt mice did not show evidence of insulin resistance or glucose intolerance (data not shown), we used only male mice for the subsequent studies.…”
Section: Resultssupporting
confidence: 89%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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