The Laryngoscope
 2001
DOI: 10.1097/00005537-200105000-00023
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A Morphological Study of Age Changes in Adult Human Auricular Cartilage With Special Emphasis on Elastic Fibers

Isamu Ito
1
,
Masato Imada
2
,
Minoru Ikeda
3
et al.

Abstract: Structural changes of auricular cartilage associated with morphological age changes of elastic fibers may be one of the causes of expansion of the auricle after reaching adulthood.

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Cited by 103 publications

(106 citation statements)
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“…Increasing h with age was observed while sGAG and HYP contents decreased. Age-related augmentation of tissue thickness is consistent with previous reports of continued growth of the auricle during adult life (Ito et al, 2001;Meijerman et al, 2007;Sforza et al, 2009). This is likely due to altered quality of the fiber network, specifically elastic fibers become increasingly fragmented and heterogeneous with age (Ito et al, 2001).…”
Section: Discussionsupporting
confidence: 89%
“…Age-related augmentation of tissue thickness is consistent with previous reports of continued growth of the auricle during adult life (Ito et al, 2001;Meijerman et al, 2007;Sforza et al, 2009). This is likely due to altered quality of the fiber network, specifically elastic fibers become increasingly fragmented and heterogeneous with age (Ito et al, 2001). Additionally, cleavage of collagen fibers has been linked in articular cartilage to increased thickness (Bank et al, 2000), and a similar mechanism could exist in AUR cartilage.…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Increasing h with age was observed while sGAG and HYP contents decreased. Age-related augmentation of tissue thickness is consistent with previous reports of continued growth of the auricle during adult life (Ito et al, 2001;Meijerman et al, 2007;Sforza et al, 2009). This is likely due to altered quality of the fiber network, specifically elastic fibers become increasingly fragmented and heterogeneous with age (Ito et al, 2001).…”
Section: Discussionsupporting
confidence: 89%
“…Age-related augmentation of tissue thickness is consistent with previous reports of continued growth of the auricle during adult life (Ito et al, 2001;Meijerman et al, 2007;Sforza et al, 2009). This is likely due to altered quality of the fiber network, specifically elastic fibers become increasingly fragmented and heterogeneous with age (Ito et al, 2001). Additionally, cleavage of collagen fibers has been linked in articular cartilage to increased thickness (Bank et al, 2000), and a similar mechanism could exist in AUR cartilage.…”
Section: Discussionsupporting
confidence: 88%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The maturity of the hEC matrix might cause better retention of GAG. In human ears, the ECM components and especially elastic fibers structurally change over the years [46]. When stained for elastin, the elastic fibers in our bEC are mainly directly located as a band around the lacunae whereas in hEC, this network extends more into the ECM, confirming what is shown previously by Ito et al [46].…”
Section: Discussionsupporting
confidence: 89%
“…In human ears, the ECM components and especially elastic fibers structurally change over the years [46]. When stained for elastin, the elastic fibers in our bEC are mainly directly located as a band around the lacunae whereas in hEC, this network extends more into the ECM, confirming what is shown previously by Ito et al [46]. This difference in elastic fibers in adult cartilage, could have protected the ECM from degradation during decellularization.…”
Section: Discussionsupporting
confidence: 87%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…Boys and men had larger ears than girls and women, a finding in accord with the previous studies [1,2,[4][5][6][7][8][9]11,26,27,30]. The sexual dimorphism in ear dimensions appears to begin with postnatal growth: at birth, and within the first 24 months of life, similar dimensions in newborn and children boys and girls were found in almost all studies [17,19,20,26].…”
Section: Discussionsupporting
confidence: 87%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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